Placental Heat Shock Protein 70 Overexpression Confers Resistance Against Oxidative Stress in Preeclampsia Aims: Preeclampsia is a hypertensive disorder of human pregnancy and a leading cause of premature delivery
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چکیده
Aims: Preeclampsia is a hypertensive disorder of human pregnancy and a leading cause of premature delivery and fetal growth retardation. The purpose of this study was to evaluate the expression of heat shock protein 70 (HSP70), both constitutive (HSC70) and induced (HSP70) forms, along with oxidative stress status in the placental tissues of normotensive (control group) and preeclamptic pregnancies.
منابع مشابه
HSP70 expression and its role in preeclamptic stress.
Preeclampsia, a hypertensive pregnancy-specific disorder, has long been analyzed for its association with cellular stress. It still remains one of the most serious complications of pregnancy. It is a multi-system disorder that affects maternal vascular function and fetal growth. The physiopathology of preeclampsia is still unclear, but an imbalance between reactive oxygen species (ROS) and anti...
متن کاملHeat Shock Protein 70 Expression Is Spatially Distributed in Human Placenta and Selectively Upregulated during Labor and Preeclampsia
Placental oxidative stress is a feature of both human labor and the pregnancy syndrome preeclampsia. Heat shock proteins (HSPs) can be induced in cells as a protective mechanism to cope with cellular stress. We hypothesized that HSP 70 would increase during labor and preeclampsia and that expression would vary in different placental zones. Samples were obtained from 12 sites within each placent...
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Introduction: Preeclampsia is a common and serious hypertensive disorder affecting approximately 5-8 % of pregnancies. The biology of the disease is complex and not understood. This disease associated with increased blood pressure more than 140/90 mmHg in the second half of pregnancy and proteinuria more than 300 mg/24 h and is considered as one of the three leading causes of maternal and fetal...
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Preeclampsia is a hypertensive disorder of pregnancy in which patients develop profound sensitivity to vasopressors, such as angiotensin II, and is associated with substantial morbidity for the mother and fetus. Enhanced vasoconstrictor sensitivity and elevations in soluble fms-like tyrosine kinase 1 (sFLT1), a circulating antiangiogenic protein, precede clinical signs and symptoms of preeclamp...
متن کاملمقایسه سطح سرمی کلسیم، فسفر و پروتئین تام در بین دو گروه خانمهای حامله سالم و دارای اختلالات فشارخون بیمارستان لقمان ، 82-1380
Background: Pre-eclampsia is characterized by hypertension development and proteinuria during pregnancy. Hypertension disorder is a leading cause of maternal and fetal morbidity and death in worldwide. Although the pathophysiology of hypertension during pregnancy is unclear, but there is consensus that early diagnosis and aggressive treatment is warranted to prevent complicated to both fetus an...
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